Scott is Chair of the Cancer Biology and Genetics Program at Memorial Sloan Kettering Cancer Center (MSKCC) in New York City and an Investigator with the Howard Hughes Medical Institute. He earned his bachelor’s degree from the University of Wisconsin-Madison and a Ph.D. from the Massachusetts Institute of Technology. Dr. Lowe began his independent research at Cold Spring Harbor Laboratory, where his group made significant contributions to understanding the p53 tumour suppressor, multi-step carcinogenesis, cellular senescence, and tumour-cell drug resistance. At MSKCC, his team integrates mouse models, genetics, and genomics to explore the interactions between tumour cells and their environment. This work has led to new discoveries relating to the genetic and epigenetic drivers of cancer evolution and how cellular senescence can influence immune surveillance and be targeted therapeutically.

During his career, Dr. Lowe has mentored over 80 trainees, many of whom have gone on to independent faculty positions. He has received numerous awards, including the Sidney Kimmel Scholar Award, Rita Allen Scholar Award, the American Association for Cancer Research (AACR) Outstanding Investigator Award and G.H.A. Clowes Award, the Paul Marks Prize, and the Alfred G. Knudsen Award from the NIH. He is an elected member of the American Academy of Arts and Sciences, the National Academy of Sciences, and the National Academy of Medicine, and is a Fellow of the AACR.