Simon is a Professor of Molecular and Population Genetics and an Honorary Consultant Gastroenterologist at the University of Oxford. His research is into the morphogenic signalling pathways that control the intestinal stem cell in homeostasis, regeneration and cancer, and he has published more than 100 peer reviewed papers in journals that include Nature, Nature Medicine, Nature Genetics, Cell Stem Cell, Gastroenterology and Gut.

Simon’s research has been recognised by the United European Gastroenterology Rising Star award in 2010, the British Society of Gastroenterology Francis Avery Jones research prize in 2015 and the CRUK Future Leaders prize in 2017.